We design personalized vaccine antigens based on tumor-specific/associated mutations commonly seen in tp53, BRCAs, PTEN, KRAS, BRAF, EGFR, and many others following next-generation sequencing approaches. This strategy also applies to other genetic diseases including amyotrophic lateral sclerosis, genetic cardiomyopathies, and polyglutamine diseases.
We have multiple vaccine candidates specifically targeting the hallmark protein aggregates in Alzheimer's Disease and Parkinson's Disease.
In the process of aging, protein aggregates are gradually deposited in various organs as the markers. We design various immunogens that help the immunity recognize and clear the aggregates-bearing cells to intervene the process.
Atherosclerosis underlies most cardiovascular diseases. We provide epitope sequences for the development of vaccines preventing the covalent buildup of extracellular matrix proteins at atherosclerotic lesion sites.
We offer antigen candidates for vaccines preventing influenza, herpesviruses, sexually transmitted infections including HIV, syphilis, chlamydia, and gonorrhea, parasite infections including toxoplasmosis, fungi infections caused by Candidas, Coccidioides, Aspergilluses and Cryptococcuses, and various bacteria infections. We provide customized design for any pathogens.
We have vaccine candidates/approaches designed to block the key mediators TNF-alpha, transglutaminase and autoimmune TCRs.
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